The course is designed to provide a critical review of cell signalling pathways. Emphasis is put on hormone-neuro transmitter classification; steroids, and thyroxin, polypeptides: growth hormones, insulin, glucagon. Amino acid-derived, classical neurotransmitters. Eicosanoids. Cell-cell signalling. Diversity of receptor types, classification and biochemistry of cell surface receptors. Hierarchical nature of hormonal control. Signalling in response to steroids/thyroxine, intracellular receptor/transcriptional regulation. Signalling through G-proteins and tyrosine kinases. Second Messengers: cAMP, IP3/ DAG: synthesis, generation in cell. Protein kinase C. Heterotrimetric G-protein role in signal transduction/sensory perception in cell types. Signalling via gated ion channels.
Small GTPases. Signal transduction and oncogenisis.- Enrolled students: No students enrolled in this course yet