The course covers the principles and advanced methods underlying the production, purification and applications of biotechnology-related products of relevance to research, industry, medicine and agriculture. Major topics of emphasis in this course include; Genetic basis of disease. Genomic, transcriptomic and proteomic approaches in research and disease detection. Mutagenesis and protein engineering. Disease treatment strategies. Isolation, culture and regeneration of embryonic and adult stem cells. Exvivo and in vivo gene therapy in regulating expression of cellular proteins. Tissue/organ generation, biomedical engineering. Cell culture and associated research/ industrial considerations. Generation of hybridomas and the production of monoclonal and humanized monoclonal antibodies. Protein production and downstream processing. Purification - tags/ chromatographic approaches. Principles and applications of plant biotechnology. Purification of products of biotech relevance from plants. Principles and applications of microbial biotechnology.
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