Welcome to Bugema University - E-Learning Platform.

The course is designed to introduce students to the basic concepts of biochemistry and toxicology of environmental pollutants. Topics to be emphasized include; Sources of xenobiotics and toxicants. Introduction to basic concepts in toxicology. Assessment of toxicity. Metabolism of xenobiotics. Phases of detoxification, Cytochrome P-450 system, conjugation and excretion reactions, biological oxidations, metabolism of benzo(a) pyrene and ethanol. Introduction to carcinogenesis, teratogenesis, immunotoxicity.

Chemical carcinogenesis. Initiators and promoters, genotoxicity, IARC and USEPA classification of carcinogens. Synthesis and toxicity of dioxins and related chlorinated and aromatic hydrocarbons. Toxicity of metals, including transition metals, detoxification by metallothioneins. Toxicity of pesticides and chemical warfare agents; their structure and mechanisms of toxicity. Air pollutants, levels and mechanisms of toxicity. Chemical risk assessment applied to human exposure situations.