The course provides an in-depth description of advanced aspects of protein particularly enzymes, their structure, and function which are relevant to biochemistry. Emphasis is put on the protein hierarchy. Protein crystallography. Solving structures by X-ray diffraction. Multidimensional NMR for protein structure determination and its comparison with crystallography. The protein structural database and their uses, and computer based application in studying proteins. The protein folding problem In vitro and In vivo. Meaning and determination of kinetic parameters of enzymes. Selected methods of probing kinetic mechanism. Site directed mutagenesis and protein engineering. In vivo and In vitro environment of enzymes. Proteomics.
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